WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=6; E=0.67; R=9.02; rawP=5.91e-05; adjP=0.0014
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117360 NA PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 9129 ENSG00000117360
2  ENSG00000104852 NA SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 6625 ENSG00000104852
3  ENSG00000105618 NA PRPF31 PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) 26121 ENSG00000105618
4  ENSG00000104897 NA SF3A2 splicing factor 3a, subunit 2, 66kDa 8175 ENSG00000104897
5  ENSG00000076924 NA XAB2 XPA binding protein 2 56949 ENSG00000076924
6  ENSG00000198563 NA DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 7919 ENSG00000198563


Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=6; E=0.86; R=6.94; rawP=0.0002; adjP=0.0024
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100934 NA SEC23A Sec23 homolog A (S. cerevisiae) 10484 ENSG00000100934
2  ENSG00000076984 NA MAP2K7 mitogen-activated protein kinase kinase 7 5609 ENSG00000076984
3  ENSG00000213676 NA ATF6B activating transcription factor 6 beta 1388 ENSG00000213676
4  ENSG00000177239 NA MAN1B1 mannosidase, alpha, class 1B, member 1 11253 ENSG00000177239
5  ENSG00000008952 NA SEC62 SEC62 homolog (S. cerevisiae) 7095 ENSG00000008952
6  ENSG00000075826 NA SEC31B SEC31 homolog B (S. cerevisiae) 25956 ENSG00000075826


Database:KEGG pathway       Name:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis       ID:00563
C=25; O=3; E=0.13; R=22.90; rawP=0.0003; adjP=0.0024
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000119227 NA PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 80235 ENSG00000119227
2  ENSG00000165282 NA PIGO phosphatidylinositol glycan anchor biosynthesis, class O 84720 ENSG00000165282
3  ENSG00000174227 NA PIGG phosphatidylinositol glycan anchor biosynthesis, class G 54872 ENSG00000174227


Database:KEGG pathway       Name:mRNA surveillance pathway       ID:03015
C=83; O=4; E=0.43; R=9.20; rawP=0.0010; adjP=0.0060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000071894 NA CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 29894 ENSG00000071894
2  ENSG00000149532 NA CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 79869 ENSG00000149532
3  ENSG00000169062 NA UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 65110 ENSG00000169062
4  ENSG00000198563 NA DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 7919 ENSG00000198563


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=13; E=5.92; R=2.20; rawP=0.0070; adjP=0.0264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000115419 NA GLS glutaminase 2744 ENSG00000115419
2  ENSG00000141429 NA GALNT1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) 2589 ENSG00000141429
3  ENSG00000103056 NA SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 55512 ENSG00000103056
4  ENSG00000157353 NA FUK fucokinase 197258 ENSG00000157353
5  ENSG00000213930 NA GALT galactose-1-phosphate uridylyltransferase 2592 ENSG00000213930
6  ENSG00000177239 NA MAN1B1 mannosidase, alpha, class 1B, member 1 11253 ENSG00000177239
7  ENSG00000139631 NA CSAD cysteine sulfinic acid decarboxylase 51380 ENSG00000139631
8  ENSG00000100288 NA CHKB choline kinase beta 1120 ENSG00000100288
9  ENSG00000165282 NA PIGO phosphatidylinositol glycan anchor biosynthesis, class O 84720 ENSG00000165282
10  ENSG00000197713 NA RPE ribulose-5-phosphate-3-epimerase 6120 ENSG00000197713
11  ENSG00000109929 NA SC5DL sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like 6309 ENSG00000109929
12  ENSG00000184381 NA PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 8398 ENSG00000184381
13  ENSG00000049239 NA H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 9563 ENSG00000049239


Database:KEGG pathway       Name:RNA degradation       ID:03018
C=71; O=3; E=0.37; R=8.06; rawP=0.0062; adjP=0.0264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000038358 NA EDC4 enhancer of mRNA decapping 4 23644 ENSG00000038358
2  ENSG00000171824 NA EXOSC10 exosome component 10 5394 ENSG00000171824
3  ENSG00000135473 NA PAN2 PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) 9924 ENSG00000135473


Database:KEGG pathway       Name:Pentose phosphate pathway       ID:00030
C=27; O=2; E=0.14; R=14.14; rawP=0.0088; adjP=0.0264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197713 NA RPE ribulose-5-phosphate-3-epimerase 6120 ENSG00000197713
2  ENSG00000049239 NA H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 9563 ENSG00000049239


Database:KEGG pathway       Name:Glycerophospholipid metabolism       ID:00564
C=80; O=3; E=0.42; R=7.16; rawP=0.0087; adjP=0.0264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100288 NA CHKB choline kinase beta 1120 ENSG00000100288
2  ENSG00000102125 NA TAZ tafazzin 6901 ENSG00000102125
3  ENSG00000184381 NA PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 8398 ENSG00000184381


Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=5; E=1.40; R=3.56; rawP=0.0138; adjP=0.0368
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000172380 NA GNG12 guanine nucleotide binding protein (G protein), gamma 12 55970 ENSG00000172380
2  ENSG00000149930 NA TAOK2 TAO kinase 2 9344 ENSG00000149930
3  ENSG00000076984 NA MAP2K7 mitogen-activated protein kinase kinase 7 5609 ENSG00000076984
4  ENSG00000100324 NA TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 10454 ENSG00000100324
5  ENSG00000184381 NA PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 8398 ENSG00000184381


Database:KEGG pathway       Name:Basal transcription factors       ID:03022
C=37; O=2; E=0.19; R=10.31; rawP=0.0161; adjP=0.0386
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162227 NA TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 10629 ENSG00000162227
2  ENSG00000112592 NA TBP TATA box binding protein 6908 ENSG00000112592




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).